Many treating shoulder impingement syndrome (SIS) can be found in clinical practice most of which happen to be in contrast to anything else by various investigators. However, an extensive treatment comparison is missing. Several broadly used electronic databases were looked for qualified studies. The end result measurements were the discomfort score and also the Constant-Murley score (CMS). Direct comparisons were performed while using conventional pair-wise meta-analysis method, while a network meta-analysis in line with the Bayesian model was utilized to calculate the outcomes of potentially possible comparisons and rank odds. Incorporated within the meta-analysis procedure were 33 randomized controlled trials involving 2300 patients. Good agreement was shown between your outcomes of the happy couple-wise meta-analyses and also the network meta-analyses. Regarding nonoperative treatments, with regards to the discomfort score, combined treatments made up of exercise along with other therapies tended to yield better effects than single-intervention therapies. Localized drug injections which were coupled with exercise demonstrated better treatment effects than every other treatments, whereas worse effects were observed when such injections were utilised alone. Concerning the CMS, most combined treatments according to exercise also shown better effects than exercise alone. Regarding surgery, based on the discomfort score and also the CMS, arthroscopic subacromial decompression (ASD) along with treatments produced from it, for example ASD coupled with radiofrequency and arthroscopic bursectomy, demonstrated better effects than open subacromial decompression (OSD) and OSD combined with injection of platelet-leukocyte gel. Exercise therapy also shown good performance. Recent results for inconsistency, sensitivity analysis, and meta-regression all supported the sturdiness and longevity of these network meta-analyses. Exercise along with other exercise-based therapies, for example kinesio taping, specific exercises, and acupuncture, are perfect treating patients in an initial phase of SIS. However, low-level laser therapy and also the localized injection of nonsteroidal anti-inflammatory medicine is not suggested. For patients who’ve a lengthy-term disease course, operative treatments might be considered, with standard ASD surgery preferred over arthroscopic bursectomy and also the open surgical way of subacromial decompression. Notwithstanding, the option of surgery ought to be made very carefully because similar outcomes can also be achieved through the implementation of exercise therapy.